If you want to interact with people then don't treat Twitter as just getting followers which don't care. I get @replies from people always telling me to follow them back, if they only follow me for they then i tell them to fuck off. I have about 180 followers, as least 50% of whom i talk to. The way i did that is i follow people who i seem to have things in common with and talk to them, usually they follow back and then i regularly talk to them. I do the same when people who have similar interests to me follow me. Talk to people, befriend people. Simples.